Liquid-to-Air assemblies cool or heat a coolant in a re-circulating liquid circuit. Heat is absorbed by an external liquid heat exchanger and moved through a liquid circuit by an external pump. Heat is absorbed by the cold side liquid heat exchanger then pumped by thermoelectric coolers through the hot side heat exchanger and dissipated to the ambient environment. This configuration is ideal for spot cooling where localization of a thermoelectric assembly is not possible due to space constraints. Common applications are imaging systems, medical diagnostics and laser systems in the industrial, semiconductor and medical markets.